Sodium Acetate → N-{2-(2-acetoxy-3-oxobutylthio)ethyl}-N'-cyano-N"-methylguanidine
Reaction equation
Cl[CH:2]([C:14](=[O:16])[CH3:15])[CH2:3][S:4][CH2:5][CH2:6][NH:7][C:8]([NH:11][C:12]#[N:13])=[N:9][CH3:10].[C:17]([O-:20])(=[O:19])[CH3:18].[Na+]>CO>[C:17]([O:20][CH:2]([C:14](=[O:16])[CH3:15])[CH2:3][S:4][CH2:5][CH2:6][NH:7][C:8]([NH:11][C:12]#[N:13])=[N:9][CH3:10])(=[O:19])[CH3:18]Participants
4
Procedure
A 50 ml two-necked flask was charged with 0.64 g of the same N-{2-(2-chloro-3-oxobutylthio)ethyl}-N'-cyano-N"-methylguanidine as used in Example 1, 10 ml of methanol, and 0.31 g of anhydrous sodium acetate, and the mixture was stirred at room temperature for 8 hours. Methanol was evaporated under reduced pressure, and water was added to the residue. The mixture was extracted with ethyl acetate and then dried over anhydrous magnesium sulfate. Ethyl acetate was evaporated under reduced pressure to give 0.57 g (yield 82%) of the desired product as a brown liquid.