Dichloromethane → HCID 85556110, compound

Reaction equation

C([NH:8][CH2:9][CH:10]([CH2:12][S:13][CH:14]([CH3:16])[CH3:15])[OH:11])(OC(C)(C)C)=O.C(Cl)[Cl:18]>>[NH2:8][CH2:9][CH:10]([CH2:12][S:13][CH:14]([CH3:16])[CH3:15])[OH:11].[ClH:18]

Participants

Reactant 2

HCID 6344Dichloromethane

HCID 131716253HCID 131716253, compound

Product 1

HCID 85556110HCID 85556110, compound

Procedure

BOC-NHCH2CH(OH)CH2SCH(CH3)2 (3.74 g, 0.015 mole) was dissolved in 75 ml CH2Cl2 and occasionally purged with HCl gas over two hours. The solvent was removed in vacuo, and the residue was triturated with Et2O. The solvent was decanted and the residue was stripped to a foam, 2.83 g. IR, NMR, and mass spectral analysis confirmed the structure.

Workup

customoccasionally purged with HCl gas over two hours
customThe solvent was removed in vacuo
customthe residue was triturated with Et2O
customThe solvent was decanted

Sources & evidence

ORD record: ord-d9dac2abfee148078775f620edc16bb6
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04895834

Reaction notes

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