Nicotinic acid, hydrazide → N-[[(E)-but-2-enylidene]amino]pyridine-3-carboxamide
Reaction equation
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[CH:11](=O)/[CH:12]=[CH:13]/[CH3:14]>CO>[C:1]([NH:9][N:10]=[CH:11]/[CH:12]=[CH:13]/[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 50 ml of methanol was suspended 22 g of nicotinic acid hydrazide. To the suspension was added dropwise 13.2 ml of crotonaldehyde, followed by stirring for 30 minutes at room temperature. Methanol was distilled away under reduced pressure, and the residue washed with ether, filtered off, and dried. Thus there was obtained 27.5 g of crotonaldehyde nicotinoyl hydrazone (mp. 144°-145° C.).
Workup
- distillationMethanol was distilled away under reduced pressure
- washthe residue washed with ether
- filtrationfiltered off
- customdried
Sources & evidence
- ORD record
- ord-1faba2d266cf4df2a6d6cb869e38a700
- Source dataset
- uspto-grants-1990_01
- Patent number
- US04895947
Reaction notes
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