HuagongsheHuagongshe Chemistry Print Report · For research reference only
(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride → 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride | HCID 3080792 | — |
| Reactant | Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester | HCID 4377704 | — |
| Product | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
Reaction Steps
The resulting product was esterified with (R)α-methoxy-α-trifluoromethylphenylacetyl chloride, and the ester was analyzed by HPLC. From the area ratio of the chromatogram, the optical yield of the product was found to be 97.2% ee.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04895979 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-e77df226a15942e0a532ac81d947a918 |
| Source note | uspto-grants-1990_01 |