HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanethiol → 5-Isopropylthio-pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanethiol | HCID 6364 | — |
| Reactant | 5-Hydroxy-2-pyrrolidone | HCID 194148 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-Isopropylthio-pyrrolidin-2-one | HCID 19868700 | — |
Reaction Steps
A mixture of 9 g of 5-hydroxy-pyrrolidin-2-one in 40 cm3 of 2-propanethiol and 5 g of Amberlite resin IR 120 H is maintained for 80 hours at ambient temperature. After diluting with ether, filtering, and concentrating under reduced pressure, 8.5 g of the expected product is obtained. m.p. 77°-79° C., crystallized from isopropyl ether. m.p. 85°-87° C. after re-crystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04897414 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-305946d9a6094476881ff00344e5235f |
| Source note | uspto-grants-1990_01 |