HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 33086Generated: October 26, 2026
p-Fluoronitrobenzene → N-(4-nitrophenyl)-N-(2-pyrid-3-ylethyl)amine
https://huagongshe.com/reaction/33086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Pyridin-3-yl)ethan-1-amine | HCID 854051 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-(4-nitrophenyl)-N-(2-pyrid-3-ylethyl)amine | HCID 23104837 | 92.8% |
Reaction Steps
2 g of 4-fluoronitrobenzene, 2.07 g of 2-(3-pyridyl)ethylamine, and 2.35 g of K2CO3 were added to a solution of 20 ml of N-methylpyrrolidinone. The reaction medium was heated at 60° C. for 16 hours and, after cooling to room temperature, was then poured into a water+ice mixture. The yellow precipitate formed was filtered off, reslurried in water, and then dried over P2O5. 3.2 g of N-(4-nitrophenyl)-N-(2-pyrid-3-ylethyl)amine (3) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07429278B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-7a84c7f876da493c8419e1d65ad26d6e |
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| Source note | uspto-grants-2008_09 |
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