Tetrafluoro-m-phenylenediamine dihydrochloride → n-(2-Pyrid-2-ylethyl)benzene-1,4-diamine dihydrochloride

HRID 33089

Reaction equation

HRID 33089 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:6][CH:5]=1)([O-])=O.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:31].Cl>[Zn].[Cl-].[NH4+].O.C(O)C>[ClH:31].[ClH:31].[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[CH2:12][CH2:11][NH:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 133017132-[2-(4-Nitroanilino)ethyl]pyridine

Product 1

HCID 69214213n-(2-Pyrid-2-ylethyl)benzene-1,4-diamine dihydrochloride

Reagents, catalysts & solvents 1

HCID 131726756HCID 131726756, compoundCatalyst

Procedure

The N-(4-nitrophenyl)-N-(2-pyrid-2-ylethyl)amine (5) obtained above was reduced with a boiling zinc/ammonium chloride/water/ethanol mixture. The corresponding amine was isolated in dihydrochloride form.

Sources & evidence

ORD record
ord-fe6fe9f925824fb6aea92d62733bbd4f
Source dataset
uspto-grants-2008_09
Patent number
US07429278B2

Linked notes

Loading…