1H-inden-1-one → 5-Hydroxy-1H-inden-1-one

HRID 331256

Reaction equation

HRID 331256 reaction equation
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Br.CC(O)=[O:14]>>[OH:14][C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[C:1](=[O:10])[CH:2]=[CH:3]2

Participants

3

Reactant 2

HCID 118153841H-inden-1-oneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 596088915-Hydroxy-1H-inden-1-one

Procedure

The indenone compound prepared in Step 5 is mixed with HBr/AcOH (1:2), and then the resulting mixture is allowed to reflux for 14 to 16 h with stirring, to obtain the 5-hydroxyindenone of formula 19.

Workup

  1. temperatureto reflux for 14 to 16 h

Sources & evidence

ORD record
ord-5a38d199137045348f995cf05f4d2bf6
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Linked notes

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