HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Piperidinoethanol → HCID 51001939, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Piperidinoethanol | HCID 18232 | — |
| Reactant | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| Reactant | 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70317432 | — |
| Product | HCID 51001939 | HCID 51001939 | 37% |
Reaction Steps
The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 61 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(piperidin-1-yl)ethanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 3 h, and being purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4) to obtain the title compound (37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877747B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-b483d7e2622f45bfb5f6653b099626a7 |
| Source note | uspto-grants-2014_11 |