2-Cyclopentyloxy-5-methanesulfonyl-benzoic acid → (4-Benzoxazol-2-yl-piperazin-1-yl)-(2-cyclopentyloxy-5-methanesulfonyl-phenyl)-methanone
Reaction equation
[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[N:21]1([C:27]2[O:28][C:29]3[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=3[N:31]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[O:28]1[C:29]2[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=2[N:31]=[C:27]1[N:21]1[CH2:22][CH2:23][N:24]([C:9]([C:8]2[CH:12]=[C:13]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:14]=[CH:15][C:7]=2[O:6][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:11])[CH2:25][CH2:26]1Participants
3
Procedure
Prepared in analogy to example 1.1 b) from 2-cyclopentyloxy-5-methanesulfonyl-benzoic acid (Example 2.3) and 2-piperazin-1-yl-benzoxazole hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate) to yield the title compound as a colorless solid.
Workup
- customThe crude material was purified by chromatography (SiO2, ethyl acetate)