tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylate

HRID 33169

Reaction equation

HRID 33169 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=2)[N:3]=1.[C:13]([O:17][C:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18]([N:20]1[CH2:25][CH2:24][N:23]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=3)[N:3]=2)[CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 6075022,6-Dichloroquinoline

Product 1

HCID 58906309Tert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylate

Procedure

Prepared in analogy to example 1.18(a) from 2,6-dichloroquinoline and piperazine-1-carboxylic acid tert-butyl ester. Crystallisation from methanol yields the title compound as a colorless solid.

Workup

  1. customCrystallisation from methanol

Sources & evidence

ORD record
ord-e0438a7b174843c8a39e6fdf9ab17a95
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Linked notes

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