HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromoquinoline → 4-Quinolin-3-yl-piperazine-1-carboxylic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromoquinoline | HCID 21413 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Product | 4-Quinolin-3-yl-piperazine-1-carboxylic acid tert.-butyl ester | HCID 58906302 | — |
Reaction Steps
Prepared in analogy to example 1.16(a) from 3-bromoquinoline and piperazine-1-carboxylic acid tert-butyl ester. Chromatography (SiO2; cyclohexane/ethyl acetate 1/1), followed by crystallization from diethyl ether/cyclohexane yields the title product as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429585B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-4db928d3fbef450ba6490b6ca93b490b |
| Source note | uspto-grants-2008_09 |