Pseudoephedrine Hydrochloride → Pseudoephedrine

Temperature

50 °C

The Pseudoephedrine Resin Complex was prepared by first dissolving 857 g of pseudoephedrine HCl in 5 liter of purified water, and then slowly adding 1,589 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurry was filtered and rinsed 3 times with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D polymer (668 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried at 50° C. in a VWR™ convection oven to the moisture content around 30%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

1. additionslowly adding 1,589 g of AMBERLITE™
2. additionThe dispersion was mixed for 4 hours and upon completion
3. custombefore decanting the supernatant
4. filtrationThe slurry was filtered
5. washrinsed 3 times with sufficient amounts of purified water
6. customThe wet resin complex was then dried in a VWR™ convection oven
7. additionKOLLICOAT™ SR-30D polymer (668 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
8. customto form a uniform mass
9. customThe wet mass was again dried at 50° C. in a VWR™ convection oven to the moisture content around 30%
10. customThe semi-dried granules were then milled through a 40 mesh screen
11. customcontinued drying under 50° C. until the moisture content
12. customThe dried granules were then milled through a 40 mesh screen

ORD record

ord-ebed9e366b014b409fd5f406d0794bfc

Source dataset

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08883217B2