Ethyl 3-bromobenzoate → 3-Cyclobutylbenzoic acid

HRID 334048

Reaction equation

HRID 334048 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7]CC)=[O:6].[Br-].[CH:14]1([Zn+])[CH2:17][CH2:16][CH2:15]1.C1(C2C(C(O)=O)=CC=CC=2)CCCC1>>[CH:14]1([C:2]2[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=2)[C:5]([OH:7])=[O:6])[CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 90488Ethyl 3-bromobenzoateHCID 227631552-Cyclopentylbenzoic acidHCID 178419766HCID 178419766, compound

Product 1

HCID 838275863-Cyclobutylbenzoic acid

Procedure

This intermediate was prepared from ethyl 3-bromobenzoate and cyclobutylzinc bromide in two steps according to the preparation of 6-cyclopentyl-benzoic acid.

Sources & evidence

ORD record
ord-392a5b975cba41a98c4adb39305ca4b7
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Linked notes

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