HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenylbenzaldehyde → 1-(Biphenyl-3-ylmethyl)-4-(3,4-dimethoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenylbenzaldehyde | HCID 121053 | — |
| Reactant | 1-(3,4-Dimethoxyphenyl)piperazine | HCID 2736207 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(Biphenyl-2-ylmethyl)-4-phenylpiperazine | HCID 71602523 | — |
| Product | 1-(Biphenyl-3-ylmethyl)-4-(3,4-dimethoxyphenyl)piperazine | HCID 71678680 | — |
Reaction Steps
166.8 mg of the target compound (0.43 mmol, 78.0%) was obtained using 1-(3,4-dimethoxyphenyl)piperazine (244.5 mg, 1.10 mmol), biphenyl-3-carbaldehyde (100 mg, 0.55 mmol) and NaBH(OAc)3 (355 mg, 1.65 mmol) according to the synthesis method of Compound 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883796B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-3d7348e785894027acab539b691831e1 |
| Source note | uspto-grants-2014_11 |