HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 33441Generated: October 25, 2026
P-Chloroacetophenone → (E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one
https://huagongshe.com/reaction/33441
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Chloroacetophenone | HCID 7467 | — |
| Reactant | N,N,N-trimethyl-1,1-bis(1-methylethoxy)amine | HCID 87682 | — |
| Product | (E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one | HCID 5375260 | — |
Reaction Steps
A solution of 1-(4-chlorophenyl)ethan-1-one (3.0 g, 19.3 mmol) and N,N, dimethylformamide diisopropylacetal (20 ml) was heated at 150° C. for 16 hours. The reaction mixture was cooled to 0° C. and treated with hexanes (20 ml). The resulting solid was collected via filtration and washed with hexanes to provide the title compound: EI-MS (m/z) 209 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07429599B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-631ef89be47649218b1ad42fd4234d81 |
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| Source note | uspto-grants-2008_09 |
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