Methyl 5-amino-6-methylnicotinate → Methyl 5-(7-bromoimidazo[1,2-a]pyridine-3-carboxamido)-6-methylnicotinate

HRID 335313

Reaction equation

HRID 335313 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11](NC3C=C(C=CC=3F)C(O)=O)=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1.[NH2:24][C:25]1[C:26]([CH3:35])=[N:27][CH:28]=[C:29]([CH:34]=1)[C:30]([O:32][CH3:33])=[O:31]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([NH:24][C:25]3[C:26]([CH3:35])=[N:27][CH:28]=[C:29]([CH:34]=3)[C:30]([O:32][CH3:33])=[O:31])=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 58662456Methyl 5-amino-6-methylnicotinateHCID 712834433-[(7-Bromo-imidazo[1,2-a]pyridine-3-carbonyl)-amino]-4-fluorobenzoic acid2×

Product 1

HCID 71282997Methyl 5-(7-bromoimidazo[1,2-a]pyridine-3-carboxamido)-6-methylnicotinate

Procedure

The title compound was prepared from 7-bromoimidazo[1,2-a]pyridine-3-carboxylic acid (Intermediate 1A, step 3) and methyl 5-amino-6-methylnicotinate (step 2) analogously to Intermediate 1A;

Sources & evidence

ORD record
ord-f05258628aa2480dac88ccb4a6c0116d
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Linked notes

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