2-Pyridinamine, 5-iodo- → 6-Iodoimidazo[1,2-a]pyridine-3-carboxylic acid

HRID 335326

Reaction equation

HRID 335326 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.BrC1C=CN2C(C(NC3[CH:23]=[C:24](C=CC=3F)[C:25]([OH:27])=[O:26])=O)=CN=C2C=1>>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:24]([C:25]([OH:27])=[O:26])=[CH:23][N:8]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 885792-Pyridinamine, 5-iodo-HCID 712834433-[(7-Bromo-imidazo[1,2-a]pyridine-3-carbonyl)-amino]-4-fluorobenzoic acid

Product 1

HCID 712833486-Iodoimidazo[1,2-a]pyridine-3-carboxylic acid

Procedure

The title compound was prepared from 5-iodopyridin-2-amine analogously to 7-bromoimidazo[1,2-a]pyridine-3-carboxylic acid (Intermediate 1A step 2 and step 3); LC-MS: Rt 1.07 mins; MS m/z 317 [M+H]+; Method 2minLC_v003

Sources & evidence

ORD record
ord-dbf35f7fe65145bda700ceb5e88e1885
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Linked notes

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