7-Aminoquinoline → HCID 178506063, compound

HRID 33549

Reaction equation

HRID 33549 reaction equation
[Br:1][C:2]1[C:7]2[NH:8][C:9](Cl)=[N:10][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[NH2:16][C:17]1[CH:26]=[C:25]2[C:20]([CH:21]=[CH:22][CH:23]=[N:24]2)=[CH:19][CH:18]=1>>[Br:1][C:2]1[C:7]2[NH:8][C:9]([NH:16][C:17]3[CH:26]=[C:25]4[C:20]([CH:21]=[CH:22][CH:23]=[N:24]4)=[CH:19][CH:18]=3)=[N:10][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 178506061HCID 178506061, compound

Product 1

HCID 178506063HCID 178506063, compound

Procedure

The reaction of 7-bromo-2-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole (135 mg, 0.45 mmol, prepared according to the procedures described in WO 2004/035549 A1) with 7-aminoquinoline (43 mg, 0.3 mmol, Synchem) under the condition of Example 2 afforded the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 407 (M+1).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-ed5f47716496455f908f350fe58bb328
Source dataset
uspto-grants-2008_09
Patent number
US07429608B2

Linked notes

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