2-Hydroxy-4-nitrobenzyl alcohol → 2-Hydroxy-4-nitrobenzaldehyde

HRID 335573

Reaction equation

HRID 335573 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[OH:12]>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[OH:12][C:4]1[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[CH:7]=[CH:8][C:3]=1[CH:2]=[O:1]

Participants

4

Reactant 1

HCID 118160942-Hydroxy-4-nitrobenzyl alcohol

Product 1

HCID 755702-Hydroxy-4-nitrobenzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

6.0 g (35.5 mmol) of 2-(hydroxymethyl)-5-nitrophenol and 3.1 g (35.5 mmol) of activated manganese (IV) oxide in 100 ml of chloroform are heated under reflux for 20 h. The mixture is filtered through kieselguhr, concentrated and dried under high vacuum. The title compound is directly reacted further.

Workup

  1. temperatureunder reflux for 20 h
  2. filtrationThe mixture is filtered through kieselguhr
  3. concentrationconcentrated
  4. customdried under high vacuum
  5. customThe title compound is directly reacted further

Sources & evidence

ORD record
ord-5e2f55c3259946c9a79615d1315f222b
Source dataset
uspto-grants-2014_11
Patent number
US08884017B2

Linked notes

Loading…