Bromine → 2-Amino-5-bromo-3-fluorobenzoic acid hydrobromide
Reaction equation
[Br:1]Br.[NH2:3][C:4]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[NH2:3][C:4]1[C:12]([F:13])=[CH:11][C:10]([Br:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Bromine (3.65 mL, 70.9 mmol) in Chloroform (250 mL) was added dropwise via an addition funnel to a suspension of 2-amino-3-fluorobenzoic acid (10 g, 64.5 mmol) in chloroform (400 mL) at RT. The solution was stirred for 12 hours at which point the resulting slurry was filtered. The solid was washed well with CH2Cl2 and dried under a stream of nitrogen to afford 2-amino-5-bromo-3-fluorobenzoic acid HBr.
Workup
- filtrationwas filtered
- washThe solid was washed well with CH2Cl2
- customdried under a stream of nitrogen
Sources & evidence
- ORD record
- ord-61abd4bdca784578aa19294a8726b651
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08883782B2
Reaction notes
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