Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → 3-bromotricyclo[3.3.1.13,7]dec-1-ylmethyl-1H-pyrazole

HRID 336587

Reaction equation

HRID 336587 reaction equation
C[C:2]1[C:6](B2OC(C)(C)C(C)(C)O2)=[C:5](C)[NH:4][N:3]=1.[Br:17]C12CC3CC(CC(CO)(C3)C1)C2.[C:30]12([CH2:40]O)[CH2:39][CH:34]3[CH2:35][CH:36]([CH2:38][CH:32]([CH2:33]3)[CH2:31]1)[CH2:37]2>>[Br:17][C:5]1[CH:6]=[CH:2][N:3]([CH2:40][C:30]23[CH2:39][CH:34]4[CH2:35][CH:36]([CH2:38][CH:32]([CH2:33]4)[CH2:31]2)[CH2:37]3)[N:4]=1

Participants

4

Reactant 3

HCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanolHCID 28029653-Bromotricyclo[3.3.1.13,7]decane-1-methanolHCID 162177133,5-Dimethylpyrazole-4-boronic acid, pinacol ester

Product 1

HCID 866812613-bromotricyclo[3.3.1.13,7]dec-1-ylmethyl-1H-pyrazole

Procedure

The title compound was prepared by substituting pyrazole for 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole and 3-bromo-1-adamantanemethanol for 1-adamantanemethanol in EXAMPLE 2A.

Sources & evidence

ORD record
ord-d98c76b0b54f4ed7821fba488de733ef
Source dataset
uspto-grants-2014_11
Patent number
US08889675B2

Linked notes

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