HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 337391Generated: October 27, 2026
Potassium Carbonate → 1,1'-(2-Nitro-[1,1'-biphenyl]-4,4'-diyl)diethanone
https://huagongshe.com/reaction/337391
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-Bromo-3-nitrophenyl)ethan-1-one | HCID 87737 | — |
| Reactant | 4-Acetylphenylboronic acid | HCID 3702122 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1,1'-(2-Nitro-[1,1'-biphenyl]-4,4'-diyl)diethanone | HCID 71272438 | — |
Reaction Steps
1-(4-bromo-3-nitrophenyl)ethanone (2 g, 8.20 mmol) and (4-acetylphenyl)boronic acid (2.016 g, 12.29 mmol), aq.K2CO3 (2M, 12.08 mL, 24.17 mmol) and Pd(PPh3)4 (0.33 g, 0.286 mmol) were dissolved in toluene (40 mL) and heated at 110° C. for 2 days. The crude product was extracted with DCM and purified on silica gel (0-100% EtOAc/Hexane). Fractions were concentrated to give the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08889726B2 |
|---|
| Source dataset | uspto-grants-2014_11 |
|---|
| ORD ID | ord-5888ef84265e42a29b1c8e06e2dd6979 |
|---|
| Source note | uspto-grants-2014_11 |
|---|
