HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 33749Generated: October 24, 2026
Lawesson's reagent → (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione
https://huagongshe.com/en/reaction/33749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethylfuran-2-yl)-methanone | HCID 11244101 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione | HCID 11508298 | — |
Reaction Steps
A solution of (4-isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanone (Example 1, 1 equiv.) and Lawesson's reagent (2.1 equiv.) in THF is heated at reflux (70° C.) for 48 h. The reaction is cooled to room temperature and the solvent is removed in vacuo. Chromatography of the residue on a silica gel column using 1-6% 2 M NH3 in MeOH/DCM) provides the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07429659B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-1110e46f7d2f433e8f777fa8a0a330e1 |
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| Source note | uspto-grants-2008_09 |
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