Isopropyl iodide → 2-Isopropoxy-5,6,7,8-tetrahydroquinoline

Reaction equation

[NH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]1=[O:11].[CH:12](I)([CH3:14])[CH3:13]>>[CH:12]([O:11][C:2]1[CH:3]=[CH:4][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[N:1]=1)([CH3:14])[CH3:13]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 2641061,2,5,6,7,8-Hexahydroquinolin-2-one

Product 1

HCID 597975232-Isopropoxy-5,6,7,8-tetrahydroquinoline

Procedure

Following the procedure described in Example 1A, step 2, 5,6,7,8-tetrahydroquinolin-2 (1H)-one and i-PrI gave the title compound as a pale yellow oil.

Sources & evidence

ORD record: ord-5a89ea86ea4646bbb1ba9d04713c9799
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429666B2

Reaction notes

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