4-Methylpyridine → 2-Pyridazin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone

Participants

Role	Name	HCID	Charge
Reactant	4-Methylpyridine	HCID 7963	—
Reactant	2-(Pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)ethan-1-one	HCID 33679727	—
Product	2-Pyridazin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone	HCID 68578034	—

Reaction Steps

Following the procedure for the preparation of 2-pyridin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone but substituting 4-methyl pyridazine for 4-picoline provided the title compound. 1H NMR (400 MHz, CDCl3) δ 9.12 (d, J=5.4 Hz, 1 H), 9.08 (d, J=8.7 Hz, 2.1 H), 8.20 (d, J=8.3 Hz, 1H), 8.07 (d, J=8.3 Hz, 1 H), 7.96 (m, 2 H), 7.83 (d, J=7.9 Hz, 1 H), 7.76 (m, 1 H), 7.62 (d, J=8.3 Hz, 1 H), 7.55 (m, 1 H) 7.38 (dd, J=5.4, 2.5 Hz, 1H), 7.09 (m, 2H), 5.44 (s, 2H) 4.23 (s, 2H); MS: (M+H m/z=356.2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07429665B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-81c1843099a64b74adc3fd95d4d1b605
Source note	uspto-grants-2008_09