2-((4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline → HCID 178505956, compound

HRID 33855

Reaction equation

HRID 33855 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:11]=[N:10][NH:9][C:8]=2[C:12]2[CH:29]=[CH:28][C:15]([O:16][CH2:17][C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]=3)=[CH:14][CH:13]=2)=[CH:3][CH:2]=1.[F:30]C1C=C(OCC2C=CC3C(=CC=CC=3)N=2)C=CC=1C(=O)CC1C=CN=CC=1>>[F:30][C:29]1[CH:28]=[C:15]([CH:14]=[CH:13][C:12]=1[C:8]1[C:7]([C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[CH:11][NH:10][N:9]=1)[O:16][CH2:17][C:18]1[CH:27]=[CH:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=1

Participants

3

Reactant 2

HCID 116105532-((4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinolineHCID 685783611-{2-Fluoro-4-(quinolin-2-ylmethoxy)-phenyl}-2-pyridin-4-yl-ethanone

Product 1

HCID 178505956HCID 178505956, compound

Procedure

Following the procedure for the preparation of 2-[-4-(4-Pyridin-4-yl-2H-pyrazol-3-yl)-phenoxymethyl}-quinoline but substituting 1-{2-Fluoro-4-(quinolin-2-ylmethoxy)-phenyl}-2-pyridin-4-yl-ethanone provided the title compound. 1H NMR (400 MHz, CDCl3) δ 8.47 (d, J=6.5 Hz, 2H), 8.22 (d, J=8.3 Hz, 1H), 8.08 (d, J=8.7 Hz, 1 H), 7.84 (s, 1H), 7.82 (m, 1H), 7.74 (m, 1H), 7.65 (d, J=8.7 Hz, 1 H), 7.55 (m, 1 H), 7.25 (m, 1 H), 7.18 (d, J=6.2 HZ, 2H), 6.85 (d, J=10.9, 2 H), 5.38 (s, 2 H); MS: (M+H m/z=397.2).

Sources & evidence

ORD record
ord-640d7f9440b74315b866028ba7bd02d6
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Linked notes

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