2-Chloro-4-methylpyridine → 2-(2-Chloro-pyridin-4-yl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone

HRID 33869

Reaction equation

HRID 33869 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]=3)=[CH:12][CH:11]=2)=[O:9])=[CH:3][CH:2]=1.[Cl:28]C1C=C(C)C=CN=1>>[Cl:28][C:2]1[CH:3]=[C:4]([CH2:7][C:8]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH2:17][C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]=3)=[CH:14][CH:15]=2)=[O:9])[CH:5]=[CH:6][N:1]=1

Participants

3

Reactant 2

HCID 772482-Chloro-4-methylpyridineHCID 336797272-(Pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)ethan-1-one

Product 1

HCID 862493242-(2-Chloro-pyridin-4-yl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone

Procedure

Following the procedure for the preparation of 2-pyridin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone but substituting 2-chloro-4-methyl pyridine provided the title compound. MS: (M+H m/z=389.0).

Sources & evidence

ORD record
ord-5970d975b6734d9494f074fbee93410d
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Linked notes

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