3-Isopropylaniline → 3-bromo-N-(3-isopropylphenyl)-5-methylbenzamide

HRID 338742Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([OH:7])=O.[CH:12]([C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18])([CH3:14])[CH3:13]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([NH:18][C:17]1[CH:19]=[CH:20][CH:21]=[C:15]([CH:12]([CH3:14])[CH3:13])[CH:16]=1)=[O:7]

Participants

Reactant 2

HCID 4586793-Isopropylaniline

HCID 34331273-Bromo-5-methylbenzoic acid

Product 1

HCID 866958603-bromo-N-(3-isopropylphenyl)-5-methylbenzamideYield 99%

Procedure

In a manner similar to that described in Preparation 41, 3-bromo-5-methylbenzoic acid (400 mg) and 3-isopropylaniline were converted to the title compound (615 mg, 99%).

Sources & evidence

ORD record: ord-569505674ad14816bf9f4b895934cad5
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889870B2

Reaction notes

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