4-(quinolin-2-ylmethoxy)benzoic Acid → 3-Chloro4-(quinolin-2-ylmethoxy)-benzoic acid

HRID 33878

Reaction equation

HRID 33878 reaction equation
N1C2C(=CC=CC=2)C=CC=1COC1C=CC(C(O)=O)=CC=1.C[O:23][C:24](=[O:44])[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH2:32][C:33]2[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=3)[N:34]=2)=[C:27]([Cl:43])[CH:26]=1>>[Cl:43][C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][C:28]=1[O:31][CH2:32][C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[N:34]=1)[C:24]([OH:44])=[O:23]

Participants

3

Reactant 2

HCID 98385524-(quinolin-2-ylmethoxy)benzoic AcidHCID 685759083-Chloro-4-(quinolin-2-ylmethoxy)-benzoic acid methyl ester

Product 1

HCID 685787133-Chloro4-(quinolin-2-ylmethoxy)-benzoic acid

Procedure

Following the procedure for the preparation of 4-(Quinolin-2-ylmethoxy)-benzoic acid but substituting 3-Chloro-4-(quinolin-2-ylmethoxy)-benzoic acid methyl ester provided the title compound. (M+H m/z=314.0).

Sources & evidence

ORD record
ord-a3fd4ec27598486486874ffb63f24d96
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Linked notes

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