2-Aminothiophenol → HCID 68279367, compound

HRID 338782

Reaction equation

HRID 338782 reaction equation
C([O-])(=O)C.[Na+].[OH:6][C:7]1[CH:8]=[C:9]([CH:12]=[C:13]([OH:15])[CH:14]=1)[CH:10]=O.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[SH:23]>C(O)(=O)C>[S:23]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[C:10]1[C:9]1[CH:12]=[C:13]([OH:15])[CH:14]=[C:7]([OH:6])[CH:8]=1

Participants

5

Reactant 3

HCID 87132-AminothiophenolHCID 943653,5-DihydroxybenzaldehydeHCID 517045Sodium Acetate

Product 1

HCID 68279367HCID 68279367, compoundYield 48.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

An acetic acid (0.8 mL) and sodium acetate (196.6 mg, 2.40 mmol) were added to a suspension including 3,5-dihydroxybenzaldehyde (91.6 mg, 0.66 mmol) and 2-aminothiophenol (0.095 mL, 0.80 mmol, purity: 90%), and then, the reaction mixture was refluxed for 2 hours. The resultant precipitate was filtered, and the filtered product was washed with water and methylene chloride to obtain a gray solid Compound 21 (78.3 mg, 48.6%).

Workup

  1. temperaturethe reaction mixture was refluxed for 2 hours
  2. filtrationThe resultant precipitate was filtered
  3. washthe filtered product was washed with water and methylene chloride

Sources & evidence

ORD record
ord-867faa4d77614f7dbf1ca34fca4ac2a0
Source dataset
uspto-grants-2014_11
Patent number
US08889881B2

Linked notes

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