Phthalic Anhydride → 2-(1-Hydroxypentan-2-yl)isoindoline-1,3-dione

HRID 339348

Reaction equation

HRID 339348 reaction equation
[C:1]1(=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])O1.[NH2:12][CH:13]([CH2:16][CH2:17][CH3:18])[CH2:14][OH:15]>>[OH:15][CH2:14][CH:13]([N:12]1[C:3](=[O:10])[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1]1=[O:11])[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 6811Phthalic AnhydrideHCID 2490172-Amino-1-pentanol

Product 1

HCID 667725062-(1-Hydroxypentan-2-yl)isoindoline-1,3-dioneYield 62%

Procedure

2-(1-hydroxypentan-2-yl)isoindoline-1,3-dione was prepared in a similar manner to example 9c using isobenzofuran-1,3-dione and 2-aminopentan-1-ol. Yield 62%. 1H NMR (500 MHz, CDCl3): δ 0.92 (t, 3H); 1.33 (m, 2H); 1.76 (m, 1H); 1.95 (m, 1H); 3.88 (m, 1H); 4.06 (m, 1H); 4.39 (m, 1H); 7.72 (m, 2H); 7.83 (m, 2H).

Sources & evidence

ORD record
ord-ac942abca4034833a06754f438bd7a05
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Linked notes

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