3-Chloro-p-anisic acid → (R)-methyl 2-(3-chloro-4-methoxybenzamido)-4-methylpentanoate

HRID 339353

Reaction equation

HRID 339353 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.Cl.[CH3:14][O:15][C:16](=[O:23])[C@@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[NH2:18]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([NH:18][C@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[C:16]([O:15][CH3:14])=[O:23])=[O:7]

Participants

3

Reactant 2

HCID 1699823-Chloro-p-anisic acidHCID 11600782D-Leucine Methyl Ester Hydrochloride

Product 1

HCID 57527984(R)-methyl 2-(3-chloro-4-methoxybenzamido)-4-methylpentanoate

Procedure

Prepared in a similar manner to example 4 using 3-chloro-4-methoxy benzoic acid and D-leucine methyl ester hydrochloride. MS (M+H, 314.10).

Sources & evidence

ORD record
ord-eff9efd56447445a92417cfd673123f0
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Linked notes

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