D-Leucine, methyl ester → 4-Methyl-2-(3-thiophen-2-yl-acryloylamino)-pentanoic acid methyl ester

HRID 339371

Reaction equation

HRID 339371 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=O.[CH3:11][O:12][C:13](=[O:20])[C@@H:14]([CH2:16][CH:17]([CH3:19])[CH3:18])[NH2:15]>>[CH3:11][O:12][C:13](=[O:20])[CH:14]([NH:15][C:8](=[O:10])[CH:7]=[CH:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:16][CH:17]([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 89967D-Leucine, methyl esterHCID 928683-Thiophen-2-ylprop-2-enoic acid

Product 1

HCID 667732054-Methyl-2-(3-thiophen-2-yl-acryloylamino)-pentanoic acid methyl ester

Procedure

Prepared in a similar manner as described in example 4 from 3-thiophen-2-yl-acrylic acid and D-leucine methyl ester. MS (M+H, 282.2).

Workup

  1. customPrepared in a similar manner

Sources & evidence

ORD record
ord-544bab8cfbcb41db9e907e676799ae5d
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Linked notes

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