Sodium Hydroxide → Sodium 6-methoxynicotinate

HRID 339380

Reaction equation

HRID 339380 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[CH:5][N:4]=1.[OH-].[Na+:14]>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O-:9])=[O:8])=[CH:5][N:4]=1.[Na+:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 586039Methyl 6-methoxypyridine-3-carboxylate

Product 1

HCID 23717611Sodium 6-methoxynicotinate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

methyl 6-methoxynicotinate (2.097 g, 12.56 mmol) was dissolved in dioxane (30 mL). An aqueous solution of NaOH (1.0N, 25 mL) was added to the solution and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure to provide 2.2 g of sodium 6-methoxynicotinate.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0482b300a3214a2a9e2d4a88299a8574
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Linked notes

Loading…