4-Heptanamine → N-(heptan-4-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 339384

Reaction equation

[CH3:1][N:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][C:4]([CH3:10])=[N:3]1.[CH3:11][CH2:12][CH2:13][CH:14]([NH2:18])[CH2:15][CH2:16][CH3:17]>>[CH3:11][CH2:12][CH2:13][CH:14]([NH:18][C:7]([C:6]1[N:2]([CH3:1])[N:3]=[C:4]([CH3:10])[CH:5]=1)=[O:9])[CH2:15][CH2:16][CH3:17]

Participants

Reactant 2

HCID 386654-Heptanamine

HCID 5877211,3-Dimethyl-1H-pyrazole-5-carboxylic acid

Product 1

HCID 57527752N-(heptan-4-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

Procedure

Prepared in a similar manner to example 4 using 1,3-dimethyl-1H-pyrazole-5-carboxylic acid and 4-heptylamine. 1H NMR (500 MHz, CDCl3): δ 0.90 (t, 6H, J=7.2 Hz), 1.41 (m, 4H), 1.50 (m, 4H), 2.27 (s, 3H), 3.77 (s, 3H), 4.09 (m, 1H), 6.49 (d, 1H), 6.53 (s, 1H). MS (M+H, 238).

Sources & evidence

ORD record: ord-11aebe6d53aa47788845123b700f5625
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08895050B2

Linked notes

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