4-Heptanamine → 1-(2,4-Dimethoxyphenyl)-3-(heptan-4-yl)urea

HRID 339407

Reaction equation

HRID 339407 reaction equation
[CH3:1][CH2:2][CH2:3][CH:4]([NH2:8])[CH2:5][CH2:6][CH3:7].[N:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[O:20][CH3:21])=[C:10]=[O:11]>>[CH3:21][O:20][C:13]1[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:12]=1[NH:9][C:10]([NH:8][CH:4]([CH2:5][CH2:6][CH3:7])[CH2:3][CH2:2][CH3:1])=[O:11]

Participants

3

Reactant 2

HCID 386654-HeptanamineHCID 6016372,4-Dimethoxyphenyl isocyanate

Product 1

HCID 113008771-(2,4-Dimethoxyphenyl)-3-(heptan-4-yl)ureaYield 88%

Procedure

Prepared in a similar manner to example 158 using heptan-4-amine and 1-isocyanato-2,4-dimethoxybenzene. Yield: 88%. mp: 172-173° C. 1H NMR (500 MHz, CDCl3): δ 0.93 (t, 6H), 1.45 (m, 8H), 3.82 (s, 3H), 3.83 (m, 1H), 3.84 (s, 1H), 4.32 (br s, 1H), 6.34 (br s, 1H), 6.49 (d, 1H), 6.50 (s, 1H), 7.71 (d, 1H). MS (M+H, 295).

Sources & evidence

ORD record
ord-596fb7c9758347f181c2cf4244652118
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Linked notes

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