(3R)-3-amino-3-phenylpropanoic acid → L-Phenylalanine

HRID 339440

Reaction equation

HRID 339440 reaction equation
N[C@@H:2]([CH2:9][C:10]([OH:12])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:13][C@H](CC(O)=O)C1C=CC=CC=1>>[NH2:13][C@H:9]([C:10]([OH:12])=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 686703(3R)-3-amino-3-phenylpropanoic acidHCID 686704(3S)-3-amino-3-phenylpropanoic acid

Product 1

HCID 6140L-Phenylalanine

Procedure

The optical purity of (S)-β-phenylalanine was calculated from the peak area of the chromatogram obtained under analysis conditions illustrated in (1) above. Furthermore, the reaction yield of (S)-β-phenylalaninewas calculated from the peak area of the chromatogram obtained under analysis conditions illustrated in (2) above. Concretely, when the reaction solution contained a solid of β-phenylalanine or a solid of L-phenylalanine, a solution obtained by collecting a part of the reaction solution containing these solids, mixing with a 0.2 mol/l hydrochloric acid solution and dissolving these solids was analyzed. The amount (g) of (S)-β-phenylalanine synthesized was calculated from the peak area of the chromatogram using a calibration curve of (S)-β-phenylalanine standards to determine the yield from (Formula 1). Yield (%)=Amount of (S)-β-phenylalanine synthesized (g)/Amount of L-phenylalanine added (g)×100  (Formula 1)

Workup

  1. customobtained under analysis conditions
  2. customobtained under analysis conditions

Sources & evidence

ORD record
ord-0819d9f57f5d4c14aba814481d948dd0
Source dataset
uspto-grants-2014_11
Patent number
US08895270B2

Linked notes

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