Tetramethyl orthocarbonate → HCID 68359229, compound
Reaction equation
[OH:1][C:2]([CH3:22])([CH3:21])[CH:3]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:10][CH:9]=1)[S:4]([NH2:7])(=[O:6])=[O:5].[C:23](OC)(OC)(OC)[O:24][CH3:25]>C(O)(=O)C>[CH3:23][O:24][C:25]1[O:1][C:2]([CH3:22])([CH3:21])[CH:3]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)=[CH:10][CH:9]=2)[S:4](=[O:5])(=[O:6])[N:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Hydroxy-2-methyl-1-(4-morpholin-4-ylmethylphenyl)propane-1-sulfonamide (350 mg) was stirred with tetramethyl orthocarbonate (5 ml) and glacial acetic acid (1 ml) at 80° C. for 16 hours. The solvents were removed under reduced pressure and the residue was used further without further purification.