L-Valinol → HCID 178448298, compound

HRID 34028

Reaction equation

HRID 34028 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:38](O)=[O:39])[CH:5]=[C:6]2[C:10]=1[N:9](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[N:8]=[C:7]2/[CH:30]=[CH:31]/[C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1.[NH2:41][C@H:42]([CH2:46][OH:47])[CH:43]([CH3:45])[CH3:44]>>[OH:47][CH2:46][C@@H:42]([NH:41][C:38]([C:4]1[CH:5]=[C:6]2[C:10](=[C:2]([F:1])[CH:3]=1)[NH:9][N:8]=[C:7]2/[CH:30]=[CH:31]/[C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1)=[O:39])[CH:43]([CH3:45])[CH3:44]

Participants

3

Reactant 2

HCID 640993L-ValinolHCID 689308447-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic Acid

Product 1

HCID 178448298HCID 178448298, compound

Procedure

By treating 200 mg of 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-carboxylic acid obtained by Example 126 and 94.5 μl L-valinol in accordance with Example 127, 102 mg of the title compound was obtained as white crystals.

Sources & evidence

ORD record
ord-c147f8ec689548fc837ab12dc8208f0e
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Linked notes

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