2-Furancarboxylic acid → Furan-2-carboxylic acid {7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2/[CH:11]=[CH:12]/[C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1.[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]([OH:27])=O>>[F:1][C:2]1[CH:3]=[C:4]([NH:19][C:25]([C:21]2[O:20][CH:24]=[CH:23][CH:22]=2)=[O:27])[CH:5]=[C:6]2[C:10]=1[N:9]([C:25]([C:21]1[O:20][CH:24]=[CH:23][CH:22]=1)=[O:27])[N:8]=[C:7]2/[CH:11]=[CH:12]/[C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1Participants
3
Procedure
Following amidation using 217 mg of 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine and 286 mg of 2-furancarboxylic acid in accordance with the method of Example 127, purification by LC-MS was carried out, to afford 143 mg of the title compound as yellow crystals.
Workup
- customwith the method of Example 127, purification by LC-MS