(Naphthalen-2-yl)boronic acid → 3-(Naphthalen-2-yl)-1-trityl-1H-pyrazolo[4,3-b]pyridine

HRID 34061

Reaction equation

HRID 34061 reaction equation
I[C:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1.[CH:30]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][C:31]=1B(O)O>>[CH:38]1[C:39]2[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:35]=[CH:36][C:37]=1[C:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2734375(Naphthalen-2-yl)boronic acidHCID 689323633-Iodo-1-trityl-1H-pyrazolo[4,3-b]pyridine

Product 1

HCID 689327003-(Naphthalen-2-yl)-1-trityl-1H-pyrazolo[4,3-b]pyridineYield 28.7%

Procedure

By treating 731 mg of 3-iodo-1-trityl-1H-pyrazolo[4,3-b]pyridine obtained by Example 418 and 340 mg of 2-naphthalene boronic acid in the manner as described in Production example 194, 210 mg of the title compound was obtained as a colorless powder.

Sources & evidence

ORD record
ord-fe5376172d2748c08c3fccc8b5ac8ca6
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Linked notes

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