HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Dimethylamino)-2-propenal → 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-5-(pyrimidin-2-yl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Dimethylamino)-2-propenal | HCID 79125 | — |
| Reactant | 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxamidine Hydrochloride | HCID 68928009 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-5-(pyrimidin-2-yl)-1H-indazole | HCID 60034727 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
36 mg of 6-fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxamidine hydrochloride obtained by Example 599 and 15 μl of 3-dimethylaminopropenal were dissolved in 1 mL of pyridine, and stirred at 120° C. for 7 hours. After distilling off the solvent, purification by LC-MS was conducted, to give 0.61 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429609B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-eba3391fdedb4d1195f66eec34e10ce3 |
| Source note | uspto-grants-2008_09 |