Formic Acid → [Oxazol-2-yl-(toluene-4-sulfonyl)-methyl]-carbamic Acid Tert-Butyl Ester

Participants

Reaction Steps

300 mg of oxazole 2-carboaldehyde was dissolved in a mixed solvent of 3 mL of methanol and 6 mL of water, added successively with 363 mg of tert-butyl carbamate, 552 mg of sodium p-toluenesulfonate and 0.76 mL of formic acid and stirred at room temperature for 16 hours and 30 minutes. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure, to afford 247 mg of the title compound as colorless crystals.

Provenance & Evidence