HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 6-Arylpyrido[2,3-d]pyrimidine deriv. 69
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Isocyanato-4-methoxybenzene | HCID 79443 | — |
| Reactant | 6-(2,6-dichlorophenyl)-2-N-[3-(4-methylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328148 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Arylpyrido[2,3-d]pyrimidine deriv. 69 | HCID 5328171 | 87% |
Reaction Steps
6-(2,6-Dichlorophenyl)-N2 -[3-(4-methyl-piperazin-1-yl)-propyl]-pyrido[2,3-d]pyrimidine-2,7-diamine (1.0 g) from Example 36 was reacted with 4-methoxyphenyl isocyanate (0.334 g) according to the general procedure of Example 37 to give 1.16 g of 1-{6-(2,6-dichlorophenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-3-(4-methoxy-phenyl)-urea, ESMS (20/80 MeOH/CH3CM+0.1% AcOH): M+ +H=595; mp 93.5°-100.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05733913 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-002722963a3747c394ad244025da8c2d |
| Source note | uspto-grants-1998_03 |