Methanol → Methyl 3-oxovalerate

HRID 34399

Reaction equation

[O:1]=[C:2]([CH2:7][CH3:8])[CH2:3][C:4]([OH:6])=[O:5].[CH3:9]O>>[O:1]=[C:2]([CH2:7][CH3:8])[CH2:3][C:4]([O:6][CH3:9])=[O:5]

Participants

Reactant 2

HCID 887Methanol

HCID 4396843-Oxopentanoic acid

Product 1

HCID 121699Methyl 3-oxovalerate

Procedure

The β-keto acid (14) is then esterified with an alkanol of formula R3 -OH to yield a β-keto ester (15). For example, 3-oxopentanoic acid is heated at reflux with methanol to yield methyl 3-oxopentanoate (15) (Scheme V, Step 3).

Sources & evidence

ORD record: ord-b4a3263de28246e393eacc908cfd091a
Source dataset: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04761420

Linked notes

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