1,3-Difluorobenzene → 6-Bromo-1-(2,4-difluorophenyl)-1-hexanone

Reaction equation

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](Cl)=[O:8].[Cl-].[Al+3].[Cl-].[Cl-].[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([C:18]1[CH:19]=[CH:20][C:15]([F:14])=[CH:16][C:17]=1[F:21])=[O:8]

Participants

Reactant 3

HCID 97411,3-Difluorobenzene

HCID 898486-Bromohexanoyl chloride

HCID 6451240Aluminum(III) Chloride

Product 1

HCID 544758096-Bromo-1-(2,4-difluorophenyl)-1-hexanone

Procedure

6-Bromohexanoyl chloride (2 g), 1,3-difluorobenzene (20 ml) and aluminum chloride (1.31 g) were reacted and treated in the same manner as in Preparation Example 105 to give 1.16 g of 6-bromo-1-(2,4-difluorophenyl)-1-hexanone.

Workup

additiontreated in the same manner as in Preparation Example 105

Sources & evidence

ORD record: ord-a6e4bc8f0a7d47789098a91f4df4b36b
Source dataset: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05864039

Reaction notes

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