1,2-Dibromoethane → 4-Hydroxypyrimidine

HRID 344680

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4](=[O:7])[NH:3][CH:2]=1.Br[CH2:9][CH2:10][Cl:11].BrCCBr>>[O:7]=[C:4]1[N:3]([CH2:9][CH2:10][Cl:11])[CH:2]=[N:1][CH:6]=[CH:5]1.[N:1]1[CH:6]=[CH:5][C:4](=[O:7])[NH:3][CH:2]=1

Participants

Reactant 3

HCID 78391,2-Dibromoethane

HCID 78491-Bromo-2-Chloroethane

HCID 206954-Hydroxypyrimidine

Product 2

HCID 206954-Hydroxypyrimidine

HCID 197725552-(1,6-Dihydro-6-oxopyrimidin-1-yl)ethyl chloride

Procedure

When an equivalent amount of 4-pyrimidone is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19, 2-(1,6-dihydro-6-oxopyrimidin-1-yl)ethyl chloride is isolated after column chromatography (4-pyrimidone, Aldrich, 34%, B).

Sources & evidence

ORD record: ord-51b4306f523143c698d0cc229d69e0d4
Source dataset: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05053411

Linked notes

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