HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 1,8-Naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-(1,3-Benzodioxol-5-yl)piperazine | HCID 2771771 | — |
| Reactant | 3-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine | HCID 9839987 | — |
| Product | 1,8-Naphthyridine | HCID 136069 | 661.4% |
| Product | HCID 53975414 | HCID 53975414 | — |
Reaction Steps
(RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-8-[3-(3,4-methylenedioxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under conditions similar to Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.59 g), (RS)-2-(3,4-methylenedioxyphenyl)piperazine (1.25 g) and sodium carbonate (0.64 g). (RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-8-[3-(3,4-methylenedioxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8 naphthyridine (2.15 g) is obtained in the form of a yellow solid, m.p. 252° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053509 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-1a2672ea7e304abca0f88808b0986ebd |
| Source note | uspto-grants-1991_10 |