Sulfuric Acid → Pyrazolo[1,5-a]pyrimidine-3-carboxamide
Reaction equation
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]#[N:11])[CH:2]=1.S(=O)(=O)(O)[OH:13]>>[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]([NH2:11])=[O:13])[CH:2]=1Participants
3
Procedure
As shown hereinabove a pyrazolo(1,5-a)pyrimidine-3-carbonitrile (4) (prepared in the manner described in U.S. Pat. Nos. 4,281,000; 4,236,005 and 4,178,499) is stirred with concentrated sulfuric acid at room temperature for from 2-20 hours. The mixture is carefully poured onto ice and the precipitate is collected, neutralized with sodium hydroxide, ammonium hydroxide or saturated sodium bicarbonate and the like and washed with water to obtain the corresponding pyrazolo(1,5-a)pyrimidine-3-carboxamide compound (3).
Workup
- customprepared in the manner
- additionThe mixture is carefully poured onto ice
- customthe precipitate is collected
- washthe like and washed with water
Sources & evidence
- ORD record
- ord-5f1fad99517f4f82985dfcf0162ae970
- Source dataset
- uspto-grants-1991_10
- Patent number
- US05059691
Reaction notes
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